同学你好，该知识点来自沪江网校《【Uni智能】雅思7分名师VIP-高中起点【10月签约班】》的课程，想要更系统的学习，欢迎进入课程学习。不仅可以和更多的同学一起学习，而且还有老师、助教随时的学习指导和知识点解答哦。

同学你好，
是有区别的，具体情况如下;
1. 关系代词 whose，引导定语从句时，既可指人，又可指物，在从句中只能作定语；of whom 只能指人；of which 只能指物，有时 whose 可以与 of whom 和 of which 互换使用。如：
The girl whose hair is golden is from England. 头发金色的那个女孩是英国人。
The house whose doors are green is an office building. 门是绿色的那座房子是办公楼。

2. “介词 + whose +名词” 引导定语从句。如：
I love my motherland, for whose good future I will work hard. 我爱我的祖国，为了她美好的未来我要努力工作。

3. 在下列情况下，一般只用 of whom 和 of which。
(1) 定语从句的主语是 few, little, some, most, many, much等时，一般只用of whom和of which。
In the room are lots of people, many of whom I don’t know. 房间里有很多人，很多人我不认识。
He has a lot of story-books, a few of which I have never read. 他有很多故事书，有几本故事书我还从未看过。

(2) 定语从句的主语是数词、形容词的最高级时，一般只用of whom和of which。如：
The old man has three children, two of whom are college students and one of whom is a manager. 那个老人有三个小孩，其中两个是大学生，另一个是经理。

(3) 定语从句的主语是all, none, both, neither, each等不定代词时，一般只用of whom和of which。如：
There are fifty students in our class, all of whom are working hard. 我们班有五十个学生，所有这五十个学生学习都刻苦。
He planted two trees last year, both of which are growing well. 去年他栽了两棵树，这两棵树都长得好。

(4) 在定语从句中作表语的定语时，一般只用of whom和of which。如：
He has three brothers, of whom Li Lei is the youngest one. 它有三兄弟，李蕾是他们中最小的一个。
There are many countries in Asia, of which China is the largest one. 亚洲有很多国家，中国是最大的一个。

祝学习愉快！